19 Nonhodgkin Lymphoma
![](https://photos.thisispiggy.com/file/wikiFiles/vdlmE5f.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/uN05T4w.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/p2ntWeW.jpg)
- different in different places of lymph nodes
- follicles: follicular lymphoma
- region surround follicle: mantle, mantle cell lymphoma
- marginal zone: outside mantle, marginal zone lymphoma
Diffuse Large B
![](https://photos.thisispiggy.com/file/wikiFiles/OYe9pVW.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/429tWF1.jpg)
- really difficult to recognize by cell
- lymphoid follicle structure obliterated
![](https://photos.thisispiggy.com/file/wikiFiles/cExEHf6.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/ZwRPn9U.jpg)
- large crab marching up to archers in stronghold (B cells in lymphoma): AIDS can cause Diffused Large B Cell Lymphoma
![](https://photos.thisispiggy.com/file/wikiFiles/LRdH3NM.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/aGTFTG1.jpg)
Follicular
![](https://photos.thisispiggy.com/file/wikiFiles/SgAfQVF.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/giahUsp.jpg)
- B cell make antibodies: heavily use IgG H chain, over express BCL 2 next to it
- Germinal center B cell frequent apoptosis with lack of BCL2
- Now: does not die
![](https://photos.thisispiggy.com/file/wikiFiles/EFig2Xs.jpg)
- feared outcome: convert to diffuse large B
![](https://photos.thisispiggy.com/file/wikiFiles/xgDe0QD.jpg)
- abundance of follicles
- histology shows centrocytes
![](https://photos.thisispiggy.com/file/wikiFiles/7gfrnDy.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/XFBRxUl.jpg)
- presence of macrophages seen in reactive lymphadenopathy
![](https://photos.thisispiggy.com/file/wikiFiles/K2TVgGB.jpg)
- reactive: some develop more than others
Mantle Cell
![](https://photos.thisispiggy.com/file/wikiFiles/p2ntWeW.jpg)
- different in different places of lymph nodes
- follicles: follicular lymphoma
- region surround follicle: mantle, mantle cell lymphoma
- marginal zone: outside mantle, marginal zone lymphoma
![](https://photos.thisispiggy.com/file/wikiFiles/OEGe0Sp.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/GsCmy1L.jpg)
- cells grow rapidly, unregulated growth
Marginal Zone
![](https://photos.thisispiggy.com/file/wikiFiles/p2ntWeW.jpg)
- different in different places of lymph nodes
- follicles: follicular lymphoma
- region surround follicle: mantle, mantle cell lymphoma
- marginal zone: outside mantle, marginal zone lymphoma
![](https://photos.thisispiggy.com/file/wikiFiles/EDa8lu2.jpg)
- marginal zones form and expands in settings of chronic inflammation
- found in portions of bodies where chronic inflammation occurs
Small
![](https://photos.thisispiggy.com/file/wikiFiles/JUhZQc5.jpg)
- can present with swollen lymph nodes and very high WBC count, like leukemia
Burkitt
![](https://photos.thisispiggy.com/file/wikiFiles/zuEVst5.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/M2Z09N0.jpg)
- rapidly dividing cells, create lots of debrid cleaned up by macrophages, clearing spaces
- cancer cells with white areas
![](https://photos.thisispiggy.com/file/wikiFiles/fQH8Lkr.jpg)
- Africa/New Guinea: high prevalence of EBV
- sporadic: any country
![](https://photos.thisispiggy.com/file/wikiFiles/kc2zghx.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/kBBf5Uo.jpg)
- B tumors association with latent EBV
![](https://photos.thisispiggy.com/file/wikiFiles/f98eyJq.jpg)
- AA bar kid with swelling jaw: Endemic or African Burkitt lymphoma = large jaw lesion and swelling
![](https://photos.thisispiggy.com/file/wikiFiles/urLI0m8.jpg)
T Cell leukemia/lymphoma
![](https://photos.thisispiggy.com/file/wikiFiles/tDlmRH9.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/rgwIwQ9.jpg)
- lymphocytosis: leukemia
- lymphadenopathy: lymphoma
- rule of thumb: T cells involve skin
- MM: no LAD, skin lesions, lymphocytosis, endemic location
Cutaneous T
![](https://photos.thisispiggy.com/file/wikiFiles/ywxLgRi.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/wGxPE2w.jpg)
- mycosis: nothing to do with fungal infection
![](https://photos.thisispiggy.com/file/wikiFiles/OAK5BEH.jpg)
- malignant cells enter blood stream
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